Systemic therapies in hepatocellular carcinoma: present and future.

@article{Bertino2013SystemicTI,
  title={Systemic therapies in hepatocellular carcinoma: present and future.},
  author={Gaetano Bertino and Isidoro Di Carlo and Annalisa Maria Ardiri and Giuseppe Stefano Calvagno and Shirin Demma and Giulia Malaguarnera and Nicoletta Bertino and Mariano Malaguarnera and Adriana Mar{\'i}n Toro},
  journal={Future oncology},
  year={2013},
  volume={9 10},
  pages={
          1533-48
        }
}
Hepatocellular carcinoma (HCC) is now the third leading cause of cancer deathsworldwide and is generally presented at an advanced stage, limiting patients' quality of life. The conventional cytotoxic systemic therapy has proved to be ineffective in HCC, since its induction several decades ago. Today it is possible to use our knowledge of molecular hepatocarcinogenesis to provide a targeted therapy. Sorafenib has demonstrated large improvements in overall survival in HCC. This review describes… CONTINUE READING
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