Systemic stress signalling: understanding the cell non-autonomous control of proteostasis

@article{Taylor2014SystemicSS,
  title={Systemic stress signalling: understanding the cell non-autonomous control of proteostasis},
  author={Rebecca C. Taylor and Kristen M. Berendzen and Andrew G Dillin},
  journal={Nature Reviews Molecular Cell Biology},
  year={2014},
  volume={15},
  pages={211-217}
}
Proteome maintenance is crucial to cellular health and viability, and is typically thought to be controlled in a cell-autonomous manner. However, recent evidence indicates that protein-folding defects can systemically activate proteostasis mechanisms through signalling pathways that coordinate stress responses among tissues. Coordination of ageing rates between tissues may also be mediated by systemic modulation of proteostasis. These findings suggest that proteome maintenance is a systemically… CONTINUE READING