Systemic steroid pretreatment improves cerebral protection after circulatory arrest.

  title={Systemic steroid pretreatment improves cerebral protection after circulatory arrest.},
  author={Dominique Shum-Tim and Christo Ivanov Tchervenkov and A. M. M. Jamal and Toni Nimeh and Chwan-yau Luo and E Chedrawy and {\'E}ric Lalibert{\'e} and A. V. Philip and Colin P. Rose and Joel Lavoie},
  journal={The Annals of thoracic surgery},
  volume={72 5},
  pages={1465-71; discussion 1471-2}
BACKGROUND This study evaluates whether systemic steroid pretreatment enhances neuroprotection during deep hypothermic circulatory arrest (DHCA) compared with steroid in cardiopulmonary bypass (CPB) prime. METHODS Four-week-old piglets randomly placed into two groups (n = 5 per group) were given methylprednisolone (30 mg/kg) into the pump prime (group PP), or pretreated intravenously 4 hours before CPB (group PT). All animals underwent 100 minutes of DHCA (15 degrees C), were weaned off CPB… CONTINUE READING
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