Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha.

@article{Chizzolini2003SystemicST,
  title={Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha.},
  author={Carlo Chizzolini and Yann Parel and Carmelina De Luca and Alan Tyndall and Anita {\AA}kesson and Agneta Scheja and J A Dayer},
  journal={Arthritis and rheumatism},
  year={2003},
  volume={48 9},
  pages={2593-604}
}
OBJECTIVE In systemic sclerosis (SSc; scleroderma), T cells infiltrate organs undergoing fibrotic changes and may participate in dysregulated production of collagen by fibroblasts. The objective of this study was to functionally characterize T cells infiltrating skin lesions in early SSc and investigate their capacity to affect production of type I collagen and interstitial collagenase (matrix metalloproteinase 1 [MMP-1]) by dermal fibroblasts. METHODS Four-color cytometric analysis was used… CONTINUE READING

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