Systemic safety of anti-VEGF drugs: a commentary

  title={Systemic safety of anti-VEGF drugs: a commentary},
  author={L. Scott and U. Chakravarthy and B. Reeves and C. Rogers},
  journal={Expert Opinion on Drug Safety},
  pages={379 - 388}
  • L. Scott, U. Chakravarthy, +1 author C. Rogers
  • Published 2015
  • Medicine
  • Expert Opinion on Drug Safety
  • Introduction: VEGF is a mediator of angiogenesis. Thus, concerns have been expressed following the use of VEGF inhibitors for the treatment of neovascular age-related macular degeneration (nAMD). Ranibizumab, and more recently aflibercept, are VEGF inhibitors licensed for the treatment of nAMD. Bevacizumab is also used but unlicensed for this application. Areas covered: A non-systematic review of nAMD trials was undertaken to investigate four outcomes: all-cause mortality, all systemic serious… CONTINUE READING
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