Systemic rotavirus infection

  title={Systemic rotavirus infection},
  author={Robert F. Ramig},
  journal={Expert Review of Anti-infective Therapy},
  pages={591 - 612}
  • R. F. Ramig
  • Published 1 August 2007
  • Medicine, Biology
  • Expert Review of Anti-infective Therapy
A new paradigm of rotavirus disease is emerging and rotavirus infection is no longer considered to be localized and confined to the GI tract. New evidence indicates that rotavirus infection is systemic. Viral antigen and infectious virus frequently enter the circulation in both children and animal model systems. Clinical case reports of systemic sequelae to rotavirus infection in children continue to accumulate, suggesting involvement in systemic disease syndromes. The use of animal models is… 
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