Systemic reovirus therapy of metastatic cancer in immune-competent mice.

@article{Hirasawa2003SystemicRT,
  title={Systemic reovirus therapy of metastatic cancer in immune-competent mice.},
  author={Kensuke Hirasawa and Sandra G. Nishikawa and Kara L. Norman and Matthew C. Coffey and Bradley G. Thompson and Chang-Soon Yoon and David Morton Waisman and Patrick Wing Kwong Lee},
  journal={Cancer research},
  year={2003},
  volume={63 2},
  pages={
          348-53
        }
}
The human reovirus is an oncolytic virus that specifically targets cancer cells with an activated Ras pathway. Because it is replication competent and highly specific for cancer cells, this virus has the potential to be an effective antimetastatic cancer agent through remote site delivery. In this study, we exploited the ability of reovirus to replicate in murine cells to test the efficacy of this virus in eliminating distal and/or metastatic tumors in immune-competent mice. We found that i.v… CONTINUE READING

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Conditionally replicating herpes vectors for cancer therapy.

  • The Journal of clinical investigation
  • 2000
VIEW 1 EXCERPT