Systemic release and protective role of IL-10 in staphylococcal enterotoxin B-induced shock in mice.

@article{Florquin1994SystemicRA,
  title={Systemic release and protective role of IL-10 in staphylococcal enterotoxin B-induced shock in mice.},
  author={Sandrine Florquin and Zoulikha Amraoui and Daniel Abramowicz and Michel Goldman},
  journal={Journal of immunology},
  year={1994},
  volume={153 6},
  pages={2618-23}
}
Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that induces the production of several pro-inflammatory cytokines, leading to a self-limited shock. In the present study, we show that SEB also triggers the systemic release of IL-10, an anti-inflammatory and immunosuppressive cytokine. Serum IL-10 was undetectable (< 1000 pg/ml) in control BALB/c mice and rose to 8500 +/- 2850 pg/ml (mean +/- SEM) 4 h after injection of 100 micrograms SEB. Cell depletion experiments and analysis of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Similar Papers

Loading similar papers…