Systemic rapamycin inhibits retinal and choroidal neovascularization in mice.

@article{Dejneka2004SystemicRI,
  title={Systemic rapamycin inhibits retinal and choroidal neovascularization in mice.},
  author={Nadine S Dejneka and Akiko Mera Kuroki and Joshua Fosnot and Waixing Tang and Michael J Tolentino and Jean Bennett},
  journal={Molecular vision},
  year={2004},
  volume={10},
  pages={964-72}
}
PURPOSE Rapamycin exhibits significant antitumor/antiangiogenic activity that is coupled with a decrease in vascular endothelial growth factor (VEGF) production and a reduction in the response of vascular endothelial cells to stimulation by VEGF. VEGF plays a significant role in neovascular pathologies of the eye, thus we tested the possibility of using rapamycin to inhibit retinal and choroidal neovascularization (CNV). METHODS CNV was induced in adult mice with laser photocoagulation… CONTINUE READING
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