Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes.

@article{Keller2009SystemicPA,
  title={Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes.},
  author={Sascha Keller and A Koenig and Frederik Marm{\'e} and Steffen Runz and Silke Wolterink and Dominique Koensgen and Alexander Mustea and Jalid Sehouli and Peter Altevogt},
  journal={Cancer letters},
  year={2009},
  volume={278 1},
  pages={73-81}
}
Exosomes are membrane vesicles that are released from many different cell types. Tumor derived-exosomes play a role in immune suppression. We hypothesized that in ovarian carcinoma patients exosomes initially produced at the local abdominal site may become systemic. We examined paired samples of ascites and blood from ovarian carcinoma patients for the presence of exosomes. We also studied the requirements for exosomal uptake by immune cells, the role of phosphatidyl-serine (PS) as uptake… CONTINUE READING
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