Systemic oxidative stress and endothelial dysfunction is associated with an attenuated acute vascular response to inhaled prostanoid in pulmonary artery hypertension patients.

@article{Gabrielli2011SystemicOS,
  title={Systemic oxidative stress and endothelial dysfunction is associated with an attenuated acute vascular response to inhaled prostanoid in pulmonary artery hypertension patients.},
  author={Luigi Gabrielli and Pablo F. Castro and Ivan Esteban Godoy and Rosemarie Mellado and Robert C Bourge and Hern{\'a}n Alca{\'i}no and Mario Chiong and Douglas Greig and Hugo E. Verdejo and Mario Navarro and Rafael L{\'o}pez and Barbra Toro and Clara Quiroga and Guillermo D{\'i}az-Araya and Sergio Lavandero and Lorena Garcia},
  journal={Journal of cardiac failure},
  year={2011},
  volume={17 12},
  pages={1012-7}
}
BACKGROUND Systemic endothelial dysfunction and increased oxidative stress have been observed in pulmonary arterial hypertension (PAH). We evaluate whether oxidative stress and endothelial dysfunction are associated with acute pulmonary vascular bed response to an inhaled prostanoid in PAH patients. METHODS Fourteen idiopathic PAH patients and 14 controls were included. Oxidative stress was assessed through plasma malondialdehyde (MDA) levels and xanthine oxidase (XO) and endothelial-bound… CONTINUE READING