Systemic or intra-amygdala injection of a benzodiazepine (midazolam) impairs extinction but spares re-extinction of conditioned fear responses.

@article{Hart2009SystemicOI,
  title={Systemic or intra-amygdala injection of a benzodiazepine (midazolam) impairs extinction but spares re-extinction of conditioned fear responses.},
  author={Genevra Hart and Justin A. Harris and Reginald Frederick Westbrook},
  journal={Learning & memory},
  year={2009},
  volume={16 1},
  pages={53-61}
}
Rats were subjected to one or two cycles of fear conditioning and extinction, injected with a benzodiazepine, midazolam, before the first or second extinction, and tested for long-term inhibition of fear responses (freezing). In Experiment 1, inhibition of context-conditioned fear was spared when midazolam was injected before the second extinction, but impaired when injected before the first. In Experiment 2, it was spared when midazolam was injected before the second extinction, but only if… CONTINUE READING
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