Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats.

Abstract

Microdialysis was used to measure extracellular levels of acetylcholine (ACh) and dopamine (DA) simultaneously in the nucleus accumbens (NAC) of freely moving rats. Systemic injection of morphine (20 mg/kg) significantly decreased ACh (30%, p less than .01) while it increased DA (55%, p less than .01). The effects of morphine were eliminated by naloxone… (More)

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@article{Rada1991SystemicMS, title={Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats.}, author={Pedro V Rada and Gregory P. Mark and Emmanuel N. Pothos and Bartley G. Hoebel}, journal={Neuropharmacology}, year={1991}, volume={30 10}, pages={1133-6} }