Systemic methotrexate therapy for psoriasis: past, present and future

@article{Dogra2013SystemicMT,
  title={Systemic methotrexate therapy for psoriasis: past, present and future},
  author={S. Dogra and R. Mahajan},
  journal={Clinical and Experimental Dermatology},
  year={2013},
  volume={38}
}
Methotrexate (MTX) has remained the backbone of the treatment for moderate to severe psoriasis ever since its first use nearly half a century ago. Over the years, its high efficacy, low cost, relative ease of administration and usefulness in concomitant psoriatic arthritis have contributed in making MTX the drug of choice in managing severe psoriasis. Although the majority of patients achieve remission of disease activity with MTX, a significant proportion may experience mild and transient… Expand
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