Systemic mesenchymal stem cell administration enhances bone formation in fracture repair but not load-induced bone formation.

Abstract

Mesenchymal stem cells (MSC) were shown to support bone regeneration, when they were locally transplanted into poorly healing fractures. The benefit of systemic MSC transplantation is currently less evident. There is consensus that systemically applied MSC are recruited to the site of injury, but it is debated whether they actually support bone formation… (More)

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