An update on pathogenesis of systemic lupus erythematosus.
- Medicine, BiologyIranian journal of kidney diseases
The pathogenesis of systemic lupus erythematosus is the perfect prototype of autoimmune disorder with multiple derangements, starting from innate immunity to adaptive immune system leading to loss of self-tolerance.
Cytokines in systemic lupus erythematosus: their role in pathogenesis of disease and possible therapeutic opportunities
- Medicine, Biology
The role of cytokines and their encoding genes are described and therapeutic applications have been discussed briefly.
Systemic Lupus Erythematosus: A Review of the Clinical Approach to Diagnosis and Update on Current Targeted Therapies.
- MedicineRhode Island medical journal
Criteria were created to aide in the diagnosis ofSystemic lupus erythematosus, focusing on clinical manifestations and antibody profiles specific to SLE, making more medications available to treat this difficult disease.
Systemic Lupus Erythematosus and Cytokine Storm
- MedicineCytokine Storm Syndrome
In this chapter, several aspects of MAS in the context of SLE are discussed, including the pathogenesis ofMAS in SLE, how MAS presents in pediatric versus adult Sle, and, finally, MAS treatment in Sle and future directions.
Conventional Treatment of Systemic Lupus Erythematosus
SLE patients frequently have numerous comorbidities, such as hyperlipidemia and hypertension, which represent risk factors for accelerated atherosclerosis and cardiovascular disease and depression, which can seriously compromise health-related quality of life.
SYSTEMIC LUPUS ERYTHEMATOSUS: DESCRIPTIONAND QUANTIFICATION OF THE DISEASE PHENOTYPE
- Medicine, Biology
The role of classifi cation criteria, disease activity, and damage indices in describing and quantifying the disease phenotype and course in patients with SLE are discussed.
Systemic Lupus Erythematosus (SLE): A 360 Degree Review
The most important updated aspects of SLE, which is an autoimmune disorder of unknown etiology, where genetic, environmental and immunological factors are believed to play an important role in its immunopathogenesis, are reviewed.
The contribution of macrophages to systemic lupus erythematosus.
- Biology, MedicineClinical immunology
The Role of NETosis in Systemic Lupus Erythematosus
- Biology, MedicineJournal of cellular immunology
This review discusses the current literature regarding the role of NETs in SLE while entertaining the possibility that NETosis could serve as therapeutic targets thereby rendering the treatment more specific and effective in comparison to the current lupus therapy.
Systemic and Biologic Agents for Lupus Erythematosus
Lupus erythematosus (LE) is an autoimmune disorder that is difficult to manage and treat and targeted therapies are infrequently used.
SHOWING 1-10 OF 480 REFERENCES
Pathogenesis of systemic lupus erythematosus
- Medicine, BiologyJournal of clinical pathology
The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably…
Systemic lupus erythematosus
- Medicine, BiologyOrphanet journal of rare diseases
Systemic lupus erythematosus is a relapsing and remitting disease, and treatment aims are threefold: managing acute periods of potentially life-threatening ill health, minimizing the risk of flares during periods of relative stability, and controlling the less life- threatening, but often incapacitating day to day symptoms.
A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus
- Biology, MedicineOrphanet Journal of Rare Diseases
A diverse array of disease-associated genes and microRNA regulatory molecules that are dysregulated through polymorphism and copy number variation have been identified; and an effect of ethnicity on susceptibility has been described.
Environment and lupus-related diseases
The traditional environmental triggers in SLE include sunlight and ultraviolet (UV) light, infections, smoking, and medications including biologics such as tumor necrosis factor alpha (TNF-a) blockers are updated and further substantiate these traditional factors in the various lupus-related syndromes.
Cytokine disturbances in systemic lupus erythematosus
- Biology, MedicineArthritis research & therapy
The present review will examine the roles of each of these cytokines in murine and human SLE, and will summarize results from clinical trials of agents that target these cytokine targets.
Treatment of lupus nephritis
- MedicineExpert review of clinical immunology
This work reviews recently reported data on current treatment regimens in LN and investigates the place of newer drugs, biologicals, in the context of the revised International Society of Nephrology/Renal Pathology Society 2003 classification.
Mechanisms of disease for the clinician: systemic lupus erythematosus.
- Medicine, BiologyAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
Therapeutic opportunities in systemic lupus erythematosus: state of the art and prospects for the new decade
- Biology, MedicineAnnals of the rheumatic diseases
A new taxonomy on the basis of mechanisms rather than clinical empiricism is predicted, leading to targeted therapy in the management of lupus, to avoid fragmentation and optimise medical care.
Solving the genetic puzzle of systemic lupus erythematosus
- BiologyPediatric Nephrology
The recent advances in the understanding of the genetics of SLE are summarized and the future directions towards fully elucidating the mechanisms of this disease are discussed.