Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis.

@article{Melis2008SystemicLO,
  title={Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis.},
  author={Lode Melis and Bernard Vandooren and E. J. Kruithof and Peggy Jacques and M De Vos and Herman Mielants and G. P. Verbruggen and Filip de Keyser and Dirk Elewaut},
  journal={Annals of the rheumatic diseases},
  year={2008},
  volume={69 3},
  pages={
          618-23
        }
}
OBJECTIVES Th17 cells are an effector T-cell population that plays a role in chronic inflammatory conditions and is dependent on IL-23 for their survival and expansion. More recently, a genetic association was discovered between polymorphisms in the gene coding for the IL-23 receptor and spondyloarthritis. This study aimed to evaluate the role of Th17-associated cytokines in spondyloarthritis pathogenesis by measuring their levels in the joints and circulation as well as correlating them with… CONTINUE READING

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