Systemic leakage and side effects of tumor necrosis factor alpha administered via isolated limb perfusion can be manipulated by flow rate adjustment.

@article{Sorkin1995SystemicLA,
  title={Systemic leakage and side effects of tumor necrosis factor alpha administered via isolated limb perfusion can be manipulated by flow rate adjustment.},
  author={Patric Sorkin and Soubhi Abu-Abid and Dorit Lev and M. Gutman and Dan Aderka and Pinchas Halpern and Avi Setton and N Kudlik and J Bar-On and Viviana Rudich},
  journal={Archives of surgery},
  year={1995},
  volume={130 10},
  pages={1079-84}
}
BACKGROUND The tolerated systemic dose of recombinant tumor necrosis factor alpha (rTNF-alpha) is very limited, since its administration leads to a severe septic shock-like condition. Its implementation in isolated limb perfusion (ILP) for metastatic melanoma or advanced soft-tissue sarcoma confined to the limb facilitates doses of rTNF-alpha 10 times higher than the systemic tolerated dose. However, with the traditional high flow rate used in ILP, systemic leakage and side effects are not… CONTINUE READING

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