Systemic ketamine inhibits hypersensitivity after surgery via descending inhibitory pathways in rats.

@article{Koizuka2005SystemicKI,
  title={Systemic ketamine inhibits hypersensitivity after surgery via descending inhibitory pathways in rats.},
  author={Shiro Koizuka and Hideaki Obata and Masayuki Sasaki and Shigeru Saito and Fumio Goto},
  journal={Canadian journal of anaesthesia = Journal canadien d'anesthesie},
  year={2005},
  volume={52 5},
  pages={498-505}
}
PURPOSE Systemic ketamine suppresses several types of chronic pain. Although ketamine is used as a general anesthetic agent, the analgesic effect of systemic ketamine for early-stage postoperative pain is not clear. We investigated the efficacy and mechanism of systemic ketamine in a rat model of postoperative pain. METHODS An incision was made in the… CONTINUE READING