Systemic iron homeostasis.

  title={Systemic iron homeostasis.},
  author={Tomas Ganz},
  journal={Physiological reviews},
  volume={93 4},
  • T. Ganz
  • Published 1 October 2013
  • Biology
  • Physiological reviews
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron from macrophages, and the release of stored iron from hepatocytes. Because iron losses are comparatively very small, iron absorption and its regulation by hepcidin and ferroportin determine total body iron content. Hepcidin is in turn feedback-regulated by plasma iron concentration and iron stores, and… 

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