Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines.

@article{Ueda2009SystemicIO,
  title={Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines.},
  author={Ryo Ueda and Mitsugu Fujita and Xinmei Zhu and Kotaro Sasaki and Edward R. Kastenhuber and Gary Kohanbash and Heather Anne McDonald and Jay Harper and Scott Lonning and Hideho Okada},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 21},
  pages={
          6551-9
        }
}
PURPOSE A variety of cancers, including malignant gliomas, overexpress transforming growth factor-beta (TGF-beta), which helps tumors evade effective immune surveillance through a variety of mechanisms, including inhibition of CD8(+) CTLs and enhancing the generation of regulatory T (T(reg)) cells. We hypothesized that inhibition of TGF-beta would improve the efficacy of vaccines targeting glioma-associated antigen (GAA)-derived CTL epitopes by reversal of immunosuppression. EXPERIMENTAL… CONTINUE READING

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Tumor localization of an anti-TGF-β antibody and its effects on gliomas.

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Advances in immunotherapeutic research for glioma therapy

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Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti-transforming growth factor-beta monoclonal antibody.

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Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti-transforming growth factor-beta monoclonal antibody.

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