Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion

@article{Natali2013SystemicIO,
  title={Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion},
  author={A. Natali and R. Ribeiro and Simona Baldi and Alberto Tulipani and Michel Rossi and Elena Venturi and Andrea Mari and M P Macedo and Ele Ferrannini},
  journal={Diabetologia},
  year={2013},
  volume={56},
  pages={1183-1191}
}
Endogenous NO inhibits insulin release in isolated beta cells and insulin-degrading enzyme activity in hepatocytes, while NO release from endothelial cells has been suggested to enhance insulin action. We assessed the overall effect of systemic inhibition of endogenous NO synthesis on glucose homeostasis in humans. Twenty-four non-diabetic volunteers underwent two hyperglycaemic (+7 mmol/l) clamps with either saline or L-NG-nitroarginine methyl ester (l-NAME, at rates of 2.5, 5, 10 and 20 μg… CONTINUE READING

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