Systemic infusion of angiotensin II into normal rats activates nuclear factor-kappaB and AP-1 in the kidney: role of AT(1) and AT(2) receptors.

@article{RuizOrtega2001SystemicIO,
  title={Systemic infusion of angiotensin II into normal rats activates nuclear factor-kappaB and AP-1 in the kidney: role of AT(1) and AT(2) receptors.},
  author={Marta Ruiz-Ortega and {\'O} Lorenzo and M{\'o}nica Rup{\'e}rez and Julia Blanco and Jes{\'u}s Egido},
  journal={The American journal of pathology},
  year={2001},
  volume={158 5},
  pages={1743-56}
}
Recent studies have pointed out the implication of angiotensin II (Ang II) in various pathological settings. However, the molecular mechanisms and the AngII receptor (AT) subtypes involved are not fully identified. We investigated whether AngII elicited the in vivo activation of nuclear transcription factors that play important roles in the pathogenesis of renal and vascular injury. Systemic infusion of Ang II into normal rats increased renal nuclear factor (NF)-kappaB and AP-1 binding activity… CONTINUE READING

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