Systemic inflammatory stimulation by microparticles derived from hypoxic trophoblast as a model for inflammatory response in preeclampsia.

@article{Lee2012SystemicIS,
  title={Systemic inflammatory stimulation by microparticles derived from hypoxic trophoblast as a model for inflammatory response in preeclampsia.},
  author={Seung Mi Lee and Roberto Romero and You Jeong Lee and In Sook Park and Chan-Wook Park and Bo Hyun Yoon},
  journal={American journal of obstetrics and gynecology},
  year={2012},
  volume={207 4},
  pages={
          337.e1-8
        }
}
OBJECTIVE To determine whether trophoblast-derived microparticles can induce different inflammatory responses of the peripheral blood mononuclear cells depending upon the state of trophoblast when the microparticles are generated. STUDY DESIGN A trophoblast-derived cell line (ATCC no. CRL-1584) was cultured under normal or hypoxic conditions. Microparticles were isolated from the cell culture supernatants (microparticles from normal trophoblast; microparticles from hypoxic trophoblast… CONTINUE READING
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