Systemic inflammation perturbs developmental retinal angiogenesis and neuroretinal function.

@article{Tremblay2013SystemicIP,
  title={Systemic inflammation perturbs developmental retinal angiogenesis and neuroretinal function.},
  author={Sophie Tremblay and Khalil Miloudi and Samaneh Chaychi and Sandra Favret and François Binet and Anna Polosa and Pierre Lachapelle and Sylvain Chemtob and Przemyslaw Sapieha},
  journal={Investigative ophthalmology & visual science},
  year={2013},
  volume={54 13},
  pages={8125-39}
}
PURPOSE Perinatal inflammatory stress in preterm babies is associated with increased rates of severe retinopathy of prematurity (ROP) and adverse neurological dysfunction. In this study, we set out to determine the consequences of severe systemic inflammatory stress on developmental retinal vascularization and evaluate the subsequent outcome on retinal function in later life. METHODS Systemic inflammatory stress was induced in C57BL/6J mouse pups by an intraperitoneal injection of… CONTINUE READING