Systemic inflammation and remote organ injury following trauma require HMGB1.

  title={Systemic inflammation and remote organ injury following trauma require HMGB1.},
  author={Ryan Levy and Kevin P. Mollen and Jose M. Prince and David J Kaczorowski and Raghuveer Vallabhaneni and Shiguang Liu and Kevin J Tracey and Michael T Lotze and David J. Hackam and Mitchell P. Fink and Yoram Vodovotz and Timothy R Billiar},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={293 4},
High-mobility group box 1 (HMGB1) is a 30-kDa DNA-binding protein that displays proinflammatory cytokine-like properties. HMGB1-dependent inflammatory processes have been demonstrated in models of sterile injury, including ischemia-reperfusion injury and hemorrhagic shock. Here, we tested the hypothesis that the systemic inflammatory response and associated remote organ injury that occur after peripheral tissue injury are highly dependent on HMGB1. Toll-like receptor 4 (TLR4) wild-type (WT… CONTINUE READING


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