Systemic inflammation and oxidative stress in hemodialysis patients are associated with down-regulation of Nrf2.

@article{Pedruzzi2015SystemicIA,
  title={Systemic inflammation and oxidative stress in hemodialysis patients are associated with down-regulation of Nrf2.},
  author={Liliana Magnago Pedruzzi and Ludmila Ferreira Medeiros de França Cardozo and Julio B Daleprane and Milena Barcza Stockler-Pinto and Elisa Bernardes Monteiro and Maurilo Leite and Nosratola D. Vaziri and Denise Mafra},
  journal={Journal of nephrology},
  year={2015},
  volume={28 4},
  pages={495-501}
}
BACKGROUND Oxidative stress and inflammation are common features and the main mediators of progression of chronic kidney disease (CKD) and its cardiovascular complications. Under normal conditions, oxidative stress activates the transcription factor, nuclear factor E2-related factor 2 (Nrf2), which is the master regulator of genes encoding antioxidant and detoxifying enzymes and related proteins. The available data on expression of Nrf2 and its key target gene products in CKD patients is… CONTINUE READING
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