Systemic inactivation and phenotypic characterization of two-component systems in expression of Streptococcus mutans virulence properties.

@article{Lvesque2007SystemicIA,
  title={Systemic inactivation and phenotypic characterization of two-component systems in expression of Streptococcus mutans virulence properties.},
  author={C{\'e}line Marie L{\'e}vesque and Richard W Mair and Julie Ann Perry and Peter C. Y. Lau and Y Li and Dennis Gerard Cvitkovitch},
  journal={Letters in applied microbiology},
  year={2007},
  volume={45 4},
  pages={398-404}
}
AIM To assess potential function of each two-component signal transduction system in the expression of Streptococcus mutans virulence properties. METHODS AND RESULTS For each two-component system (TCS), the histidine kinase-encoding gene was inactivated by a polymerase chain reaction (PCR)-based deletion strategy and the effects of gene disruption on the cell's ability to form biofilms, become competent, and tolerate acid, osmotic, and oxidative stress conditions were tested. Our results… CONTINUE READING

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