Systemic immunotoxin treatment inhibits formation of human breast cancer metastasis and tumor growth in nude rats.

@article{Engebraaten2000SystemicIT,
  title={Systemic immunotoxin treatment inhibits formation of human breast cancer metastasis and tumor growth in nude rats.},
  author={Olav Engebraaten and Gowsala P. Sivam and Siri Juell and Oystein Fodstad},
  journal={International journal of cancer},
  year={2000},
  volume={88 6},
  pages={970-6}
}
Adjuvant chemotherapy in breast cancer patients has had limited success, which is possibly because of lack of effect on non-proliferating cells accompanied by the emergence of drug-resistant cell clones. Since immunotoxins (ITs) are known to exert proliferation-independent cytotoxicity, we investigated the efficacy of systemically administered anti-carcinoma ITs in nude rat models, simulating micrometastatic disease. The monoclonal antibodies MOC31, BM7 and 425.3, which recognize epithelial… CONTINUE READING

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