Systemic immunoglobulin light chain amyloidosis

@article{Merlini2018SystemicIL,
  title={Systemic immunoglobulin light chain amyloidosis},
  author={Giampaolo Merlini and Angela Dispenzieri and Vaishali Sanchorawala and Stefan O. Sch{\"o}nland and Giovanni Palladini and Philip N. Hawkins and Morie A. Gertz},
  journal={Nature Reviews Disease Primers},
  year={2018},
  volume={4},
  pages={1-19}
}
Systemic immunoglobulin light chain amyloidosis is a protein misfolding disease caused by the conversion of immunoglobulin light chains from their soluble functional states into highly organized amyloid fibrillar aggregates that lead to organ dysfunction. The disease is progressive and, accordingly, early diagnosis is vital to prevent irreversible organ damage, of which cardiac damage and renal damage predominate. The development of novel sensitive biomarkers and imaging technologies for the… 
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