Systemic immune responses in sheep, induced by a novel nano-bead adjuvant.

@article{Scheerlinck2006SystemicIR,
  title={Systemic immune responses in sheep, induced by a novel nano-bead adjuvant.},
  author={Jean-Pierre Y Scheerlinck and Simone E. Gloster and Anita Gamvrellis and Patricia L. Mottram and Magdalena Plebanski},
  journal={Vaccine},
  year={2006},
  volume={24 8},
  pages={1124-31}
}
Although a number of adjuvants are currently approved for use in veterinary species, only alum has been widely used in humans. While it induces strong antibody responses, cell mediated responses are often low and inflammatory reactions at the site of injection are common. We investigated the immunological properties of a novel nano-bead adjuvant in a sheep large-animal model. In contrast to alum, antigen covalently coupled to nano-beads induced substantial cell mediated responses along with… CONTINUE READING