Systemic hypothermia increases PAI-1 expression and accelerates microvascular thrombus formation in endotoxemic mice

Abstract

INTRODUCTION Hypothermia during sepsis significantly impairs patient outcome in clinical practice. Severe sepsis is closely linked to activation of the coagulation system, resulting in microthrombosis and subsequent organ failure. Herein, we studied whether systemic hypothermia accelerates microvascular thrombus formation during lipopolysacharide (LPS… (More)

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