Systemic herpes simplex infection in a newborn treated with intravenous idoxuridine.

@article{Partridge1968SystemicHS,
  title={Systemic herpes simplex infection in a newborn treated with intravenous idoxuridine.},
  author={Jane Partridge and Rosemary R. Millis},
  journal={Archives of disease in childhood},
  year={1968},
  volume={43 229},
  pages={377-81}
}
Idoxuridine (5-iodo-2'-deoxyuridine) is a thymidine analogue which interferes with deoxyribonucleic acid (DNA) metabolism and inhibits herpes simplex virus multiplication. Its systemic use is limited by toxicity. Calabresi (1965) has recommended that it be used only for severe infections with DNA-containing viruses, or for malignant disease. We report a newborn infant with severe herpes simplex infection; idoxuridine was used systemically with some evidence of effectiveness, though cessation of… CONTINUE READING

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