Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.

@article{Vile1994SystemicGT,
  title={Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.},
  author={R G Vile and Jeffery A Nelson and S A Castleden and H. G. Chong and Ian R. Hart},
  journal={Cancer research},
  year={1994},
  volume={54 23},
  pages={6228-34}
}
Previously we have demonstrated safe and effective transfer of the HSVtk cytotoxic gene to primary murine melanoma tumors by direct injection of plasmid and retroviral vectors in which the HSVtk gene is driven by the tissue-specific tyrosinase promoter. However, for general clinical application such forms of therapy should, ideally, be effective against disseminated metastases. We report here that the number of recently established lung metastases of B16 melanoma in C57BL mice treated with… CONTINUE READING
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Development of antitumor immunity following thymidine kinasemediated killing ofexperimental brain tumors

  • D. Barbs, J. Hardin, M. Sadelain, F. H. Gage
  • Proc . Nail . Acad . Sci . USA
  • 1994

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