Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

  title={Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration},
  author={John V. Pluvinage and T. Wyss-Coray},
  journal={Nature Reviews Neuroscience},
  • John V. Pluvinage, T. Wyss-Coray
  • Published 2020
  • Medicine
  • Nature Reviews Neuroscience
  • A rapidly ageing population and a limited therapeutic toolbox urgently necessitate new approaches to treat neurodegenerative diseases. Brain ageing, the key risk factor for neurodegeneration, involves complex cellular and molecular processes that eventually result in cognitive decline. Although cell-intrinsic defects in neurons and glia may partially explain this decline, cell-extrinsic changes in the systemic environment, mediated by blood, have recently been shown to contribute to brain… CONTINUE READING
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