Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

@article{Pluvinage2020SystemicFA,
  title={Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration},
  author={John V. Pluvinage and T. Wyss-Coray},
  journal={Nature Reviews Neuroscience},
  year={2020},
  volume={21},
  pages={93-102}
}
  • John V. Pluvinage, T. Wyss-Coray
  • Published 2020
  • Medicine
  • Nature Reviews Neuroscience
  • A rapidly ageing population and a limited therapeutic toolbox urgently necessitate new approaches to treat neurodegenerative diseases. Brain ageing, the key risk factor for neurodegeneration, involves complex cellular and molecular processes that eventually result in cognitive decline. Although cell-intrinsic defects in neurons and glia may partially explain this decline, cell-extrinsic changes in the systemic environment, mediated by blood, have recently been shown to contribute to brain… CONTINUE READING
    19 Citations

    Figures, Tables, and Topics from this paper

    Stem Cells of the Aging Brain
    • 4
    • PDF
    Proteomic examination of the neuroglial secretome: lessons for the clinic
    • 1
    Synergy between amyloid-β and tau in Alzheimer’s disease
    • 16
    The accelerated aging model reveals critical mechanisms of late-onset Parkinson’s disease
    • 2
    A longitudinal study of the post-stroke immune response and cognitive functioning: the StrokeCog study protocol
    It's in Our Blood: A Glimpse of Personalized Medicine.

    References

    SHOWING 1-10 OF 125 REFERENCES
    Normal aging induces A1-like astrocyte reactivity
    • 346
    • PDF
    Inflammasome signalling in brain function and neurodegenerative disease
    • 151