Systemic exposure of the parent drug oxaliplatin during hyperthermic intraperitoneal perfusion

@article{Mahteme2008SystemicEO,
  title={Systemic exposure of the parent drug oxaliplatin during hyperthermic intraperitoneal perfusion},
  author={Haile Mahteme and Inger Wallin and Bengt Glimelius and Lars A P{\aa}hlman and H. Henrik Ehrsson},
  journal={European Journal of Clinical Pharmacology},
  year={2008},
  volume={64},
  pages={907-911}
}
To evaluate the perfusate and systemic kinetics of oxaliplatin during hyperthermic intraperitoneal chemotherapy (HIPEC) using a selective analytical technique. HIPEC was carried out in eight patients by the open abdomen coliseum technique for 30 min at 41.5-43°C with an average of 427 mg/m2 of oxaliplatin in 5% dextrose solution. Blood and perfusate samples were collected during the perfusion. Additional blood samples were taken up to 2 h after the end of perfusion. The analysis was performed… CONTINUE READING