Systemic envenomation caused by the wandering spider Phoneutria nigriventer, with quantification of circulating venom

@article{Bucaretchi2008SystemicEC,
  title={Systemic envenomation caused by the wandering spider Phoneutria nigriventer, with quantification of circulating venom},
  author={F{\'a}bio Bucaretchi and Sueli Moreira de Mello and Ronan Jos{\^e} Vieira and Ronei Luciano Mamoni and Maria Heloisa Souza Lima Blotta and Edson Antunes and Stephen Hyslop},
  journal={Clinical Toxicology},
  year={2008},
  volume={46},
  pages={885 - 889}
}
Introduction. Bites by Phoneutria spp. spiders are common in Brazil, although only 0.5–1% result in severe envenomation, with most of these occurring in children. Cases of systemic envenomation in adults are very unusual, and no serum venom levels have been previously quantified in these cases. Case report. A 52-year-old man was bitten on the neck by an adult female Phoneutria nigriventer. Immediately after the bite, there was intense local pain followed by blurred vision, profuse sweating… Expand
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Abstract The changes induced in the mean arterial blood pressure of anaesthetised rats following the administration of armed spider ( Phoneutria nigriventer ) venom have been investigated. TheExpand
Investigation of the haemodynamic effects of Phoneutria nigriventer venom in anaesthetised rabbits.
TLDR
It is concluded that PNV can induce central as well as peripheral haemodynamic effects and seems to be mediated by the activation of cardiovascular centres which in turn lead to an increase in the sympathetic outflow to the periphery. Expand
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The intramuscular administration of antivenom did not show significant effects on venom toxicokinetic curves and on patients recovery time, however, the same amount ofAntivenom administered by intravenous route clear rapidly the blood free venom toxins. Expand
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In conclusion, accidents involving the genus Phoneutria are common in the region of Campinas, with the highest risk groups being children under 10 years of age and adults over 70 years ofAge. Expand
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TLDR
It was shown that patients with systemic manifestations of envenoming had significantly higher plasma venom concentrations than patients with only local pain at the site of the sting. Expand
Phoneutria nigriventer (armed spider) venom induces increased vascular permeability in rat and rabbit skin in vivo.
TLDR
In rats, PNV-induced oedema was markedly reduced either by previous treatment of the animals with the histamine H1 antagonist mepyramine and the serotonin antagonist methysergide or when venom was dialysed, indicating a major role for histamine and serotonin. Expand
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TLDR
It is demonstrated that PNV contains non-dialyzable components, probably peptides, that are responsible for the contractile activity on rabbit veins and pulmonary artery strips and that the spasmogenic activity induced by dialyzed PNV was greatly reduced by incubating the venom with trypsin. Expand
Activation by Phoneutria nigriventer (armed spider) venom of tissue kallikrein‐kininogen‐kinin system in rabbit skin in vivo
TLDR
Results indicate that the oedema produced by Phoneutria nigriventer venom is dependent on the activation of the tissue kallikrein‐kinin system. Expand
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TLDR
The toxicokinetic parameters of the toxic fraction of Androctonus australis garzonii venom in the absence and after antivenom immunotherapy, in experimentally envenomed rabbits are determined and it is concluded that this minimal effective dose of antivenoms has to be injected precociously, by intravenous route, to achieve an efficient immunotherapy. Expand
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