Systemic effects of severe trauma on the function and apoptosis of human skeletal cells.

@article{Eid2006SystemicEO,
  title={Systemic effects of severe trauma on the function and apoptosis of human skeletal cells.},
  author={Karim Eid and Ludwig Labler and Wolfgang Ertel and Otmar L Trentz and Marius Keel},
  journal={The Journal of bone and joint surgery. British volume},
  year={2006},
  volume={88 10},
  pages={1394-400}
}
Systemic factors are believed to be pivotal for the development of heterotopic ossification in severely-injured patients. In this study, cell cultures of putative target cells (human fibroblastic cells, osteoblastic cells (MG-63), and bone-marrow stromal cells (hBM)) were incubated with serum from ten consecutive polytraumatised patients taken from post-traumatic day 1 to day 21 and with serum from 12 healthy control subjects. The serum from the polytraumatised patients significantly stimulated… CONTINUE READING