Systemic effects of intra-articular corticosteroids

@article{Habib2009SystemicEO,
  title={Systemic effects of intra-articular corticosteroids},
  author={G. Habib},
  journal={Clinical Rheumatology},
  year={2009},
  volume={28},
  pages={749-756}
}
  • G. Habib
  • Published 2009
  • Medicine
  • Clinical Rheumatology
The objective of this study was to review all the published articles in the English literature about the systemic effects of intra-articular corticosteroid injection (IACI) in humans. [...] Key Method Reports were searched through Pubmed using the terms intraarticular or intra-articular and steroids, corticosteroids, or glucocorticosteroids up and including the year 2007. Reports were also located through references of articles. Only objective findings outside the injected joint were included. The overwhelming…Expand

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TLDR
The finding of systemic effects of borderline significance on cortisol at 14 days fits the expected late effects due to low solubility of triamcinolone hexacetonide. Expand
Intra-articular steroids: Confounder of clinical trials
TLDR
It is recommended that the frequency with which i-a injections are used in drug efficacy studies is reported and that they are avoided in the 3 months preceding an outcome measurement if ESR or CRP are being used as outcome measures. Expand
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TLDR
A literature review suggests that judicious use of intra- and periarticular corticosteroids is very helpful in temporarily reducing pain and inflammation in musculoskeletal structures and may facilitate increased motion and function in selected cases. Expand
Steroid psychosis after an intra-articular injection
TLDR
Intra-articular steroid injections are a well recognised treatment for rheumatoid arthritis and osteoarthritis with an inflammatory component and depo-medrone (methylprednisolone acetate) 40 mg is sufficient to induce maximum suppression. Expand
Systemic effects of epidural and intra-articular glucocorticoid injections in diabetic and non-diabetic patients.
TLDR
The administration of three local cortivazol injections was followed by suppression of the corticotropic axis that persisted beyond 21 days after epidural injection and recovered more rapidly after intra-articular injection. Expand
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TLDR
It is suggested that decreased adrenocortical secretion, as reflected in depressed cortisol levels, can result from a single, low-dose, intra-articular or intramuscular injection of depot corticosteroids. Expand
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TLDR
In the short term, polyarticular IA injection was better than IM corticosteroid, as shown by ACR improvement criteria and number of adverse effects. Expand
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TLDR
In experienced hands, intraarticular corticosteroid therapy may be a safe and effective tool in the treatment of chronic arthritis in childhood and long-term follow-up is mandatory. Expand
The systemic effect of intraarticular administration of corticosteroid on markers of bone formation and bone resorption in patients with rheumatoid arthritis.
TLDR
It is suggested that IA administration of corticosteroid has no net effects on bone resorption and only a transient systemic effect on bone formation, which may be better for bone metabolism than continuous use of orally administered corticosterone. Expand
Cushing's syndrome after intra-articular and intradermal administration of triamcinolone acetonide in three pediatric patients.
TLDR
The possibility of hypothalamic-pituitary-adrenal axis suppression should be considered in patients who have received intra-articular or intradermal steroid injections, particularly in those who have had multiple or relatively high doses. Expand
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