Systemic effects of implanted prostheses made of cobalt-chromium alloys
@article{Michel2004SystemicEO, title={Systemic effects of implanted prostheses made of cobalt-chromium alloys}, author={Rolf Michel and M. Nolte and Michael Reich and F. L{\"o}er3}, journal={Archives of Orthopaedic and Trauma Surgery}, year={2004}, volume={110}, pages={61-74} }
SummarySystemic effects of Co-Cr alloy/polyethylene hip joint prostheses were investigated using instrumental neutron activation to determine the concentrations of up to 16 elements. First, in a prospective study whole blood and serum taken from 10 patients from 1 day before to 90 days after implantation were analyzed. Secondly, in a retrospective study whole blood and serum from 23 patients who had had prostheses in place for up to 18 years were analyzed. For comparison, normal trace element…
88 Citations
Synchrotron analysis of human organ tissue exposed to implant material.
- MedicineJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
- 2018
Chromium speciation in the blood of metal-on-metal hip implant patients
- Medicine
- 2017
The analysis showed that Cr released from hip implants preferentially distributed into serum and not RBC, indicating that the form of Cr present in blood of hip implant patients was in the forms of non-toxic Cr(III).
Contamination by metallic elements released from joint prostheses.
- MedicineMedical engineering & physics
- 2004
Serum cobalt levels after metal-on-metal total hip arthroplasty.
- MedicineThe Journal of bone and joint surgery. American volume
- 2003
Systemic cobalt release from Metasul metal-on-metal articulations was demonstrated throughout the five-year study period and the median serum cobalt concentrations were found to be slightly above the detection limit and remained in a constant range.
Differences in metal ion release following cobalt-chromium and oxidized zirconium total knee arthroplasty.
- MedicineActa orthopaedica Belgica
- 2010
There does not appear to be any significant rise in serum metal ion levels following total knee arthroplasty several years after implantation, and no statistically significant differences were found between the groups.
Changes of concentrations of the elements Co, Cr, Sb, and Sc in tissues of persons with joint implants
- MedicineBiological Trace Element Research
- 2008
Elevated levels of Co and Cr were found in several organs of deceased implant bearers (CoCr-alloy/polyethylene joint prostheses) by means of instrumental and radiochemical neutron activation analysis…
Effect of biomaterial on integrity and life of artificial hip
- Materials Science
- 2016
Hip replacement is a surgical procedure in which parts of the hip joint are removed and replaced with artificial parts, which is known as the prosthesis. Metallic alloys are used for prosthesis, its…
Cobalt, chromium and molybdenum ions kinetics in the human body: data gained from a total hip replacement with massive third body wear of the head and neuropathy by cobalt intoxication
- MedicineArchives of Orthopaedic and Trauma Surgery
- 2011
Early diagnosis of high metal wear can be ascertained with mass spectrometry and after revision high levels of metal ions can only be reduced with repeated chelating treatment.
Elevated serum cobalt with metal-on-metal articulating surfaces.
- MedicineThe Journal of bone and joint surgery. British volume
- 1997
The findings indicate that metal-on-metal bearings generate some systemic release of cobalt, which is consistent with iatrogenic cobalt loading.
Interpreting cobalt blood concentrations in hip implant patients
- MedicineClinical toxicology
- 2014
These studies indicate that significant systemic effects of cobalt will not occur below blood cobalt concentrations of 300 μg/L in most persons, and patients with metal-containing hip implants who exhibit signs or symptoms potentially related to polycythemia, hypothyroidism, neurological, or cardiac dysfunction should be clinically evaluated for these conditions.
References
SHOWING 1-10 OF 53 REFERENCES
Trace element burdening of human tissues due to the corrosion of hip-joint prostheses made of cobalt-chromium alloys
- Materials Science, MedicineArchives of orthopaedic and traumatic surgery
- 2004
A comparison of the tissue analyses with the corrosion experiments demonstrates that the distribution patterns of the corrosion products in the tissues are influenced by both the corrosion process and the biochemical properties of the corroding products.
Neutron activation analysis of human tissues, organs and body fluids to describe the interaction of orthopaedic implants made of cobalt-chromium alloy with the patients organisms
- Medicine
- 1987
The results demonstrate that there are high enrichments of corrosion products in several tissues and organs and that also blood and serum reveal the presence of the metal implants in the trace element levels, increasing shortly after implantation and pertaining during the entire implantation time.
[Tissue burden with exogenous trace elements caused by roentgen contrast media in bone cements].
- MedicineZeitschrift fur Orthopadie und ihre Grenzgebiete
- 1983
In 44 patients undergoing a change of total hip prosthesis, made of Co-Cr alloy and at one point with a Refobacin-Palacos chain we analyzed samples of the hip joint capsule and fascia lata. Using…
Corrosion behaviour of stainless steel implants in biological media
- Materials Science
- 1981
The corrosion behaviour of orthopaedic metal implants was studied in an animal experiment in which 30 rabbits had stainless steel plates implanted after a varization osteotomy of the tibiae of their…
Cobalt toxicity after McKee hip arthroplasty.
- MedicineThe Journal of bone and joint surgery. British volume
- 1975
Seven patients are described in whom McKee hip arthroplasties became unsatisfactory after periods varying from nine months to four years, and six of these patients were cobalt-positive but nickel- and chrome-negative on patch testing.
Trace elements in human body fluids and tissues.
- Biology, MedicineCritical reviews in clinical laboratory sciences
- 1985
Critically selected reference values are set forth for trace element levels in human blood plasma or serum, packed blood cells, urine, lung, liver, kidney, and skeletal muscle tissue in an effort to settle the currently flourishing confusion.
Certification of a second-generation biological reference material (freeze-dried human serum) for trace element determinations
- Environmental Science
- 1988
Metal Carcinogenesis
- MedicineAnnals of the New York Academy of Sciences
- 1988
Experimental and epidemiologic evidence in recent years has clearly shown that metal speciation is an urgent problem for risk estimation in metal carcinogenesis and the most important recent progress has been published for nickel and ~hromium.