Systemic effects of implanted prostheses made of cobalt-chromium alloys

@article{Michel2004SystemicEO,
  title={Systemic effects of implanted prostheses made of cobalt-chromium alloys},
  author={Rolf Michel and M. Nolte and Michael Reich and F. L{\"o}er3},
  journal={Archives of Orthopaedic and Trauma Surgery},
  year={2004},
  volume={110},
  pages={61-74}
}
SummarySystemic effects of Co-Cr alloy/polyethylene hip joint prostheses were investigated using instrumental neutron activation to determine the concentrations of up to 16 elements. First, in a prospective study whole blood and serum taken from 10 patients from 1 day before to 90 days after implantation were analyzed. Secondly, in a retrospective study whole blood and serum from 23 patients who had had prostheses in place for up to 18 years were analyzed. For comparison, normal trace element… 
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Systemic cobalt release from Metasul metal-on-metal articulations was demonstrated throughout the five-year study period and the median serum cobalt concentrations were found to be slightly above the detection limit and remained in a constant range.
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There does not appear to be any significant rise in serum metal ion levels following total knee arthroplasty several years after implantation, and no statistically significant differences were found between the groups.
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Hip replacement is a surgical procedure in which parts of the hip joint are removed and replaced with artificial parts, which is known as the prosthesis. Metallic alloys are used for prosthesis, its…
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Early diagnosis of high metal wear can be ascertained with mass spectrometry and after revision high levels of metal ions can only be reduced with repeated chelating treatment.
Elevated serum cobalt with metal-on-metal articulating surfaces.
TLDR
The findings indicate that metal-on-metal bearings generate some systemic release of cobalt, which is consistent with iatrogenic cobalt loading.
Interpreting cobalt blood concentrations in hip implant patients
TLDR
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