Systemic effects of cigarette smoke exposure in the guinea pig.

  title={Systemic effects of cigarette smoke exposure in the guinea pig.},
  author={Esther Ardite and Victor I Peinado and Roberto A Rabinovich and Jos{\'e} C Fern{\'a}ndez-Checa and Josep Roca and Joan Albert Barber{\`a}},
  journal={Respiratory medicine},
  volume={100 7},
Chronic obstructive pulmonary disease is associated with systemic effects including reduced body weight, oxidative stress and altered circulating TNFalpha levels. The present study was aimed to investigate whether chronic exposure to cigarette smoke induces these systemic changes in a guinea pig model. Seven animals/group were exposed to the smoke of seven cigarettes/day, 5 days/week, during 2, 4 and 6 months (chronic exposure). Three animals/group were sacrificed immediately, 3 h or 24 h after… CONTINUE READING