Systemic effect of cannabinoids on the spontaneous firing rate of locus coeruleus neurons in rats.

@article{Mendiguren2006SystemicEO,
  title={Systemic effect of cannabinoids on the spontaneous firing rate of locus coeruleus neurons in rats.},
  author={Aitziber Mendiguren and Joseba Pineda},
  journal={European journal of pharmacology},
  year={2006},
  volume={534 1-3},
  pages={
          83-8
        }
}
Previous reports have described modulation of noradrenergic activity by cannabinoid receptors. The aim of the present research was to examine the effect of two synthetic cannabinoid CB1/CB2 receptor agonists, R-(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)-methyl]pyrrolol-[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl) methanone (WIN 55212-2) and (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol (CP 55940), on the spontaneous activity of locus coeruleus… CONTINUE READING

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