Systemic delivery of siRNA via LCP nanoparticle efficiently inhibits lung metastasis.

@article{Yang2012SystemicDO,
  title={Systemic delivery of siRNA via LCP nanoparticle efficiently inhibits lung metastasis.},
  author={Yang Claire Yang and Jun Li and Feng Liu and Leaf Huang},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2012},
  volume={20 3},
  pages={609-15}
}
Targeted delivery remains the major challenge for the application of small interfering RNA (siRNA). We have developed a lipid/calcium/phosphate (LCP) nanoparticle (NP) to improve siRNA delivery efficiency. The LCP NP was prepared by using microemulsion technology to form calcium/phosphate (CaP) core and further coated with cationic lipids. The final NP was grafted with polyethylene glycol (PEG) and anisamide (AA) ligand on the surface to target sigma receptor-expressing B16F10 melanoma cells… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Recent advances in siRNA delivery.

Biomolecular concepts • 2015
View 14 Excerpts
Highly Influenced

siRNA delivery to the lung: what's new?

Advanced drug delivery reviews • 2014
View 19 Excerpts
Highly Influenced

Development of Small RNA Delivery Systems for Lung Cancer Therapy

International journal of molecular sciences • 2015
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Application of calcium phosphate nanoparticles in biomedicine

M Epple, K Ganesan, +3 authors S Neumann
J Mater Chem • 2010

Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery.

Journal of controlled release : official journal of the Controlled Release Society • 2010

Calcium carbonate/CaIP6 nanocomposite particles as gene delivery vehicles for human vascular smooth muscle cells

TY Cheang, SM Wang, +3 authors C Yao
J Mater Chem • 2010

Nano-structured composites based on calcium phosphate for cellular delivery of therapeutic and diagnostic agents

M Zhang, K Kataoka
Nano Today • 2009

Similar Papers

Loading similar papers…