Systemic complications of the cosmetic use of skin‐bleaching products

  title={Systemic complications of the cosmetic use of skin‐bleaching products},
  author={Antoine Mah{\'e} and Fatimata Ly and Jean-Luc Perret},
  journal={International Journal of Dermatology},
A large number of women originating from sub-Saharan Africa, as well as some men, use skin-lightening products for cosmetic purposes. 1 The complications of this practice are first and foremost dermatologic. 2 However, the nature and methods of use of skin-lightening products, which are often applied to the whole body over a number of years, expose users to certain additional risks, connected with the passage into the systemic circulation of the active constituents in question. This has… 

Overview of skin whitening agents with an insight into the illegal cosmetic market in Europe

An overview of the mode of action and potential side‐effects of cosmetic legal and illegal whitening agents, and the pattern of use of these types of products is provided.

Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners

Insight is provided into the mechanisms involved in melanin synthesis and the biological assays available to attest the lightening activity of individual ingredients and the legislation dealing with the use of skin lighteners is discussed.

Skin bleaching: highlighting the misuse of cutaneous depigmenting agents

  • OE DadzieA. Petit
  • Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2009
This current discussion within the dermatological community on the safety of hydroquinone provides a unique opportunity to raise awareness about skin bleaching.

Self-use of Skin Bleaching Products among Female Attending Family Medicine Clinic at Prince Mansour Military Hospital, Taif 2017

The lifetime use of skin bleaching agents was relatively high divided evenly on cosmetic and curative purposes, while the level of awareness about these agents is low since a considerable proportion of them agreed to use agents from unknown sources.

Skin bleaching: A neglected form of injury and threat to global skin

Results indicate skin bleaching poses a serious public health risk and threat to skin safety and called for increased governmental and individual/community intervention to address this growing problem.

Mercury contamination in facial skin lightening creams and its health risks to user

[First cases of squamous cell carcinoma associated with cosmetic use of bleaching compounds].



[An epidemiologic survey on the cosmetic use of bleaching agents by the women of Bamako (Mali)].

The results of a survey conducted in Bamako among women aged from 15 to 45 years in order to evaluate the prevalence of this practice and its socio-economic factors found that bleaching was particularly frequent in unmarried women, literate women and female students.

[Depigmentation for cosmetic purposes: prevalence and side-effects in a female population in Senegal].

The prevalence of use of depigmenting agents in this first published hospital series confirms the widespread nature of this phenomenon in Senegal and reports the first report of a dose-effect between use ofdepigmentation agents and diabetes and hypertension, probably via the effect of topical steroids.

Skin diseases associated with the cosmetic use of bleaching products in women from Dakar, Senegal

The cosmetic use of bleaching products is considered a common practice in dark‐skinned women from sub‐Saharan Africa, but there are few studies on this subject.

[Hypothalamo-hypophyseal-adrenal hypofunction caused by the use of bleaching cosmetics in Senegal].

The results show conclusively that an excessive corticosteroids charge among users who could be exposed to systemic adverse effects is found among users with a more than 10 years use of bleaching agents.

Wide use of skin-lightening soap may cause mercury poisoning in Kenya.

La dépigmentation cosmétique à Dakar (Sénégal) : facteurs socio-économiques et motivations individuelles

In order to evaluate the reasons for the cosmetic use of skin bleaching products, a questionnaire was proposed to a sample of 368 women presenting at a dermatological centre in Dakar. According to

Adrenal insufficiency and diabetes mellitus secondary to the use of topical corticosteroids for cosmetic purpose.

It is suggested that chronic use of high dose topical corticosteroid containing creams should be ruled out in patients presenting with Hypothalamo-Pituitary-Adrenal hypofunction.

Unregulated use of clobetasol propionate

The gene for EDSIV has been identified as the COL3A1 gene, located at 2q31±q32, encoding the chains of type III procollagen, and a 31-year-old white female referred to the authors' department with suspected EDS IV was referred to us.

Nephrotic Syndrome in Adult Africans in Nairobi

The use of mercury-containing skin-lightening creams in the patients studied seemed to be particularly associated with a “minimal-change” (“light-negative”) renal glomerular lesion, this lesion being present in half of the patients.

The toxicology of hydroquinone--relevance to occupational and environmental exposure.

  • A. DeCaprio
  • Biology, Medicine
    Critical reviews in toxicology
  • 1999
Hydroquinone (HQ) is a high-volume commodity chemical used as a reducing agent, antioxidant, polymerization inhibitor, and chemical intermediate. It is also used in over-the-counter (OTC) drugs as an