Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE study.

@article{Yehoshua2014SystemicCI,
  title={Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE study.},
  author={Zohar Yehoshua and Carlos Alexandre de Amorim Garcia Filho and Renata Portella Nunes and Giovanni Gregori and Fernando Marcondes Penha and Andrew A. Moshfeghi and Kang Zhang and Srinivas R. Sadda and William J Feuer and Philip J. Rosenfeld},
  journal={Ophthalmology},
  year={2014},
  volume={121 3},
  pages={693-701}
}
PURPOSE To evaluate the effect of eculizumab, a systemic inhibitor of complement component (C5), on the growth of geographic atrophy (GA) in patients with age-related macular degeneration (AMD). DESIGN Prospective, double-masked, randomized clinical trial. PARTICIPANTS Patients with GA measuring from 1.25 to 18 mm(2) based on spectral-domain optical coherence tomography imaging. METHODS Patients were randomized 2:1 to receive intravenous eculizumab or placebo over 6 months. In the… CONTINUE READING

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