Systemic but not intraocular Epo gene transfer protects the retina from light-and genetic-induced degeneration.

@article{Rex2004SystemicBN,
  title={Systemic but not intraocular Epo gene transfer protects the retina from light-and genetic-induced degeneration.},
  author={Tonia S Rex and Mariacarmela Allocca and Luciano Domenici and Enrico Maria Surace and Albert M. Maguire and Arkady L. Lyubarsky and Alessandro Cellerino and Jean Bennett and Alberto Auricchio},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2004},
  volume={10 5},
  pages={855-61}
}
Molecules with neurotrophic activity are being evaluated for treatment of retinitis pigmentosa in animal models. In particular, great interest has been focused recently on erythropoietin (Epo). Evidence of its neurotrophic activity comes mainly from data demonstrating photoreceptor protection in a rodent light-damage model through systemic administration of a recombinant form of this hormone. Our goal was to test whether Epo retinal gene transfer can rescue or delay photoreceptor cell death. We… CONTINUE READING