Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy.

  title={Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy.},
  author={Samuel F. Kim and George Buchlis and Zvi Gregory Fridlender and Jing Sun and Veena Kapoor and Guanjun Cheng and Andrew D. Haas and Hung Kam Cheung and Xiamei Zhang and Michael J. Corbley and Larry Robert Kaiser and Leona E Ling and Steven M. Albelda},
  journal={Cancer research},
  volume={68 24},
Locally produced transforming growth factor-beta (TGF-beta) promotes tumor-induced immunosuppression and contributes to resistance to immunotherapy. This article explores the potential for increased efficacy when combining immunotherapies with TGF-beta suppression using the TGF-beta type I receptor kinase inhibitor SM16. Adenovirus expressing IFN-beta (Ad.IFN-beta) was injected intratumorally once in established s.c. AB12 (mesothelioma) and LKR (lung cancer) tumors or intratracheally in a Kras… CONTINUE READING
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