Systemic bioavailability and cardiopulmonary effects of 0.5% timolol eyedrops

  title={Systemic bioavailability and cardiopulmonary effects of 0.5% timolol eyedrops},
  author={J M Korte and Timo J Kaila and Matti K. Saari},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
Background. To investigate the pharmacological basis of systemic side effects of ophthalmic timolol, we estimated the systemic bioavailability of 0.5% timolol eyedrops and compared cardiopulmonary effects of intravenous and ophthalmic timolol. Methods. In a randomized crossover study we administered 0.2 mg timolol either intravenously or ocularly to eight healthy volunteers. After drug administration we measured heart rate, arterial blood pressure, forced expiratory volume in 1 s, forced vital… CONTINUE READING
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Beta-blocking effects of timolol at low plasma levels

  • T Kaila, R Huupponen, +4 authors L Salminen
  • Clin Pharmacol Ther
  • 1990
Highly Influential
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