Systemic antivenom and skin necrosis after green pit viper bites

@article{Chotenimitkhun2008SystemicAA,
  title={Systemic antivenom and skin necrosis after green pit viper bites},
  author={Runyawan Chotenimitkhun and Ponlapat Rojnuckarin},
  journal={Clinical Toxicology},
  year={2008},
  volume={46},
  pages={122 - 125}
}
Introduction. As systemic effects of viper venoms can be neutralized by antivenom, local tissue damage, particularly necrosis of the skin, has become a more significant problem. The goal of this study is to evaluate the effectiveness of antivenom in preventing dermatonecrosis in envenomated patients with severe coagulopathy. Methods. Retrospective review of medical records of patients who were envenomated by green pit vipers (Trimeresurus albolabris or T. macrops) following bites on fingers or… Expand
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References

SHOWING 1-10 OF 19 REFERENCES
Prognostic factors of green pit viper bites.
TLDR
The predictors of systemic bleeding were the combination of thrombocytopenia and prolonged venous clotting time and bite sites away from digits, and negative skin test results do not exclude the possibility of antivenin allergy. Expand
Efficacy of antivenom in the treatment of severe local envenomation by the hump-nosed viper (Hypnale hypnale).
TLDR
It is concluded that polyspecific snake antivenom is not indicated for severe local envenomation by the hump-nosed viper. Expand
Randomized comparative trial of three monospecific antivenoms for bites by the Malayan pit viper (Calloselasma rhodostoma) in southern Thailand: clinical and laboratory correlations.
TLDR
Three monospecific antivenom for Malayan pit viper (MPV) (Calloselasma rhodostoma) were compared in Southern Thailand, where this species is the most common cause of snake bite morbidity, and the clinical efficacy of these antivenoms against local necrosis remains equivocal. Expand
Clinical trial of two antivenoms for the treatment of Bothrops and Lachesis bites in the north eastern Amazon region of Brazil.
TLDR
Investigation of whether a specific antivenom raised against the venom of B. atrox, the most important Amazon snake species from a medical point of view, was necessary for the treatment of patients in this region indicated that both antivenoms were equally effective in reversing all signs of envenoming detected both clinically and in the laboratory. Expand
An open, randomized comparative trial of two antivenoms for the treatment of envenoming by Sri Lankan Russell's viper (Daboia russelii russelii).
TLDR
The new antivenom is safer than Haffkine antivenm but, to avoid repeated doses, an initial dose higher than 1 g is needed in the treatment of Sri Lankan Russell's viper envenoming. Expand
Crotaline snake bite in the Ecuadorian Amazon: randomised double blind comparative trial of three South American polyspecific antivenoms
TLDR
All three antivenoms can be recommended for the treatment of snakebites in this region, though the reactogenicity of Brazilian and Colombian antivenom is a cause for concern. Expand
Clinical patterns of bleeding following Russell's viper and Green pit viper bites in adults.
TLDR
Clinical features and laboratory investigations following bites by Russell's viper and Green pit viper were described and thrombocytopenia and increased fibrinolytic activity were observed in addition to defibrination. Expand
A randomized, double-blind, placebo-controlled trial of antivenom for local effects of green pit viper bites.
TLDR
It is suggested that intravenous antivenom could accelerate local oedema resolution in humans, however, the degree is not clinically significant, and, therefore, general use is not recommended. Expand
Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA.
TLDR
It is suggested that administration of peptidomimetic metalloproteinase inhibitors or CaNa2EDTA at the site of venom injection may represent a useful alternative to complement antivenoms in the neutralization of venom-induced local tissue damage. Expand
A national hospital-based survey of snakes responsible for bites in Thailand.
TLDR
The technique of hospital-based collection, labelling and preservation of dead snakes brought by bitten patients is recommended when rapid assessment of a country's medically important herpetofauna is required. Expand
...
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