Systemic antibody responses to the immunodominant p23 antigen and p23 polymorphisms in children with cryptosporidiosis in Bangladesh.

@article{Borad2012SystemicAR,
  title={Systemic antibody responses to the immunodominant p23 antigen and p23 polymorphisms in children with cryptosporidiosis in Bangladesh.},
  author={Anoli J Borad and Geneve M. 214 Al - Qahtani Allison and David J. Wang and Sabeena Ahmed and Mohammad Mahbubul Karim and Anne V. Kane and Joy Moy and Patricia L. Hibberd and Sitara Swarna Rao Ajjampur and Gagandeep Kang and Stephen B. Calderwood and Edward T. Ryan and Elena N. Naumova and Wasif Ali Zafarali Khan and Honorine D Ward},
  journal={The American journal of tropical medicine and hygiene},
  year={2012},
  volume={86 2},
  pages={214-22}
}
Cryptosporidium is a major cause of diarrhea in children in developing countries. However, there is no vaccine available and little is known about immune responses to protective antigens. We investigated antibody responses to p23, a putative vaccine candidate, in children in Bangladesh with cryptosporidiosis and diarrhea (cases) and uninfected children with diarrhea (controls), and p23 gene polymorphisms in infecting species. Serum IgM, IgG, and IgA responses to p23 were significantly greater… CONTINUE READING